Serena is the female Pokemon Trainer for the upcoming game, Pokemon X and Y. According to the anime, she appears to have known Ash Ketchum before and have been childhood friends with him ever since. Serena met Ash from the time they attended Professor Oak's Pokemon summer camp in Pallet Town. During that time, she got lost in the middle of a forest while trying to find her group. Just then, a wild Poliwag jumped out of the bushes and scared her, causing her to fall on the ground and hurt her knee. Scared and upset, she called out for her mother for help. But moments later, someone came out of the bushes calling for Poliwag. It was Ash. He too was wondering through the forest only to be looking for Poliwag. While he was looking for it, he stumbled upon the young and frightened girl. Seeing how incredibly hurt she is, he bandages her knee up with a clean, blue handkerchief. Then he lended her his hand and helped her stand up on her feet. After that, he escorted her back to the campsite. Ever since their first encounter, Serena kept that handkerchief and used it as a memory of the day she first met Ash.