James Heller is the main protagonist of Prototype 2.
James Heller was a Sergeant for the Marine Corps. He lives in New York City with his wife and daughter. However, he is forced to leave them for a war at overseas.
Becoming a virus monster
When he returned to New York, Heller finds out his family had been dead due to the unleashing of the Blacklight Virus. Because of that, he joined the Marines in fighting against the infection. What they didn't know of is that he fights only to die by the monsters.
While fighting against the monsters, Heller got mortally wounded, and he finally gets his wish of dying. However, Alex Mercer, the protagonist of the first game, has been watching him taking down the virus monsters, yet he survives. He then infects him with the virus.
Heller has now become a monster that can never die. Along with that, he discovers Alex is responsible for releasing the virus, thus started the murder of his family. As a result, he plans on seeking revenge on Alex for all this.